I Took FlexAgain & I’m Joint Pain Free (My 2024 Review)

FlexAgain is my go-to joint pain supplement, which I take daily. There’s a reason it’s ranked as my best joint supplement. I’ve tried dozens of joint supplements, and every time I try something else, it doesn’t come close to FlexAgain.

So, what makes FlexAgain unique? Simply put, it uses the correct dosages of almost every ingredient that can fit into a capsule-based supplement regimen with 11 fully dosed and scientifically backed ingredients.

FlexAgain uses the highest-yield extracts, meaning they get more into their pills than most competitors.

Pros

• 11 premium ingredients.
• Supported by the latest scientific research and clinical trials.
• No reported side effects.
• Manufactured in FDA-registered facilities.
• Most comprehensive joint supplement.
• Excellent reviews across all websites and social media, including many independent review sites.
• 90-day money-back guarantee.
• Made in the USA.

Cons

• Not the cheapest joint supplement.

FlexAgain Ingredients

Omega-3 Fatty Acids

Omega-3 fatty acids are essential for joint health. But specifically, EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid).

ALA found in plants is not that useful as the body loses 85%, converting it to something that can be used for joint health. This means you’re looking for algae and fish oils only.

It’s important to note that FlexAgain uses algae extract, which is high in DHA and EPA, and dosed over 1000mg, which aligns with the clinical trials.

Omega-3 fatty acids have anti-inflammatory properties that can help reduce inflammation, which is a crucial factor in various joint diseases, including rheumatoid arthritis and osteoarthritis. In several trials, they’ve actually been shown to be more effective than NSAIDs for both pain and mobility ^[1][2].

Additionally, it has been shown to prolong cartilage health, with studies consistently showing that omega-3 can decrease the breakdown of cartilage and levels of inflammatory biomarkers, thus slowing the progression of osteoarthritis and other similar conditions.

Omega-3s are one of the most well-backed ingredients for overall joint health, improving arthritis, and potentially as effective as NSAIDs for relieving joint pain.

Ginger and Blue Galangal Extract 250mg

FlexAgain uses a standardized dose of 60mg of hydroxy methoxyphenyl, whereas the extract studied to be as effective as 3 grams of ginger was standardized to half that.

Ginger has anti-inflammatory properties that can help reduce inflammation, which is a crucial factor in various joint diseases, including rheumatoid arthritis and osteoarthritis ^[3].

Ginger has also been shown to help reduce pain intensity and duration in several conditions, including joint pain caused by rheumatoid arthritis and other degenerative diseases ^[4].

Like Ginger, Blue Galangal may help decrease inflammation associated with arthritis. This is believed to be due to the same gingerols ^[5]. The studies that found hydroxy methoxyphenyl to be effective used a combination of galangal and ginger extract.

The systematic reviews and meta-analyses on gingerol extracts for pain are incredibly positive.

Curcumin extract 500mg

Curcumin, which comes from turmeric, has been studied for its potential benefits in joint health, particularly osteoarthritis ^[6].

It’s important to make sure you’re getting curcumin extract when it comes to joint support supplements. Many cheaper supplements use standard turmeric, which is less than 12% curcumin extract!

Several studies on curcumin have shown that it can perform well as a prescription option—for example, a BMC study of 139 individuals with knee osteoarthritis symptoms ^[7].

Over a month, participants received either the NSAID diclofenac (50 mg, twice daily) or curcumin (500 mg). Both treatments similarly alleviated arthritis symptoms, with curcumin resulting in fewer reported side effects as you’d expect, although there were some reports of upset stomachs.

In addition, in another placebo-controlled trial of 101 adults with knee osteoarthritis, the curcumin group showed a significant reduction in the Knee Injury and Osteoarthritis Outcome Score (KOOS) for knee pain and numeric knee pain ratings ^[6].

Most curcumin studies show significant improvements in quality of life, pain, stiffness, mobility, and inflammatory markers, which are signs of joint issues.

Glucosamine HCL 400mg – Chondroitin 250mg

I’m covering these two ingredients together as chondroitin works with glucosamine HCl. Even though several studies on glucosamine are done specifically on knee osteoarthritis, it does seem to be effective in general for many people with OA ^[8].

One of the biggest studies, involving 1,625 individuals with hip or knee osteoarthritis, determined that glucosamine supplements did improve joint pain but didn’t significantly improve joint mobility. Other studies have shown that they do improve joint pain ^[9].

For example, a 2015 study found a significant improvement in pain levels when people took glucosamine and chondroitin together ^[10].

However, the study did not improve pain when chondroitin was taken separately, which suggests that chondroitin is generally considered to help the body process glucosamine.

Some studies have found that glucosamine increases water retention in joints, which boosts cartilage synthesis.

There isn’t much evidence to support this. However, this water retention does improve cartilage suppleness and block enzymes that break down cartilage.

Some studies found evidence that chondroitin might help by itself, but the improvements may be too small to affect patients.

Boswellic Acid 100mg

Boswellic Acid is the extract from Boswellia Serrata. It’s another correctly dosed and well-backed ingredient.

One of the most robust clinical studies spanning six months on Boswellia demonstrated consistent enhancements in joint comfort, including a reduction in pain by over 70% by the end of the study ^[11].

Additionally, stiffness decreased by 25% after the first 30 days and up to 72% at six months. Participants using the extract also reported a 71% improvement in physical function by the study’s conclusion.

A systematic review and meta-analysis found that boswellia and its extract may relieve pain and stiffness and improve joint function in patients with osteoarthritis ^[12]. At least 100 mg of boswellia and its extract is recommended for 4 weeks of treatment.

Even MRI results showed that the joint space in the subjects taking Boswellia saw limited joint space narrowing in their knees, while subjects in the placebo group experienced more narrowing. Changes in biomarkers of cartilage degradation validated this.

Bromelain 100 mg

Bromelain is a protein-digesting enzyme derived from pineapples. This may sound odd until you learn that one of the proteins it breaks down causes inflammation. It’s another well-studied ingredient and seems to be quite effective in general.

A review of clinical studies found that bromelain’s anti-inflammatory and pain-relieving properties make it an effective treatment for pain, soft tissue swelling, and joint stiffness associated with osteoarthritis ^[13].

Additionally, bromelain has repeatedly demonstrated anti-inflammatory properties ^[14]. It helps support healthy joints by protecting cartilage health by decreasing oxidative stress and the genetic expression of compounds that trigger inflammation and pain.

Interestingly, it is shown to be even more effective when combined with curcumin, with a study finding that the two significantly reduced the production of inflammation and pain markers ^[15].

Resveratrol 100mg

While resveratrol is more well-known for its brain health benefits, it has recently been studied for alleviating joint pain, and the research seems to be positive so far. It’s probably the least well-backed ingredient in FlexAgain, but it’s looking very promising.

One of the most interesting studies showed that regular treatment with resveratrol inhibited NF-kappa B, which in turn prevents further markers involved in the progression of arthritis ^[16].

Many other trials are in animals and test tubes, but the couple done in humans do look promising either way.

Methylsulfonylmethane 50mg

Methylsulfonylmethane (MSM) is a sulfur-containing compound found in plants, animals, and humans. The dose is a little low for it to be optimal for joint pain relief, which is my one gripe in my FlexAgain review.

MSM has been shown to benefit those with joint degeneration, a common cause of pain in the knees, back, hands, and hips.

It significantly reduces inflammation in your body and inhibits the breakdown of cartilage. A study of 100 people over 50 found that treatment with a supplement containing MSM for 12 weeks decreased pain, stiffness, and swelling in the joints compared to a placebo ^[17].

Vitamin D 15 mcg, Vitamin K2 70mcg

Vitamin D and Vitamin K2 are essential nutrients that significantly maintain joint health. Here are some key findings from recent studies:

Vitamin D supplementation is beneficial for the prevention of osteoarthritis. Patients with rheumatoid arthritis who have a higher risk of osteoporotic fractures and experience greater joint pain are advised to take Vitamin D supplements ^[18].

Vitamin D can help with pain reduction, making it a potential joint pain supplement. It’s worth noting that more than half of the over-50s population is deficient in vitamin D ^[19].

Vitamin K2 activates osteocalcin, a protein that helps bind calcium to the bone matrix, contributing to bone mineralization and strength. Vitamin K2 has shown potential for impacting joint health through its bone support mechanism and anti-inflammatory action ^[20].

Vitamin K2 contributes to decreased articular cartilage calcification, meaning it helps maintain healthy joints by preventing further cartilage breakdown ^[21].

Clinical trials have demonstrated that Vitamin K2 maintains or even increases bone mineral density. It also may help prevent fractures, even in older patients who have already developed osteoporosis.

FlexAgain Price

Depending on your bulk package, you can get FlexAgain for under $2 per day. Less than a cup of coffee to feel and move better. Here’s how the price breaks down per bundle.

Joint Supplement	1 Bottle	3 Bottles	6 Bottles
FlexAgain	$69.47 ($2.31 per serving)	$182.01 ($2.02 per serving)	$289.99 ($1.61 per serving)

FlexAgain also offers a 90-day money-back guarantee, so you can try it for yourself risk-free.

FlexAgain Benefits

Targets Pain

FlexAgain contains ingredients clinically proven to reduce pain from joint injuries and arthritis, such as resveratrol, vitamin D3, omega-3s, and curcumin.

This powerful blend targets the root causes of joint pain, giving you the best chance of finding effective relief.

Reduces Stiffness

This supplement combines some of the best natural over-the-counter anti-inflammatory compounds available, like bromelain, boswellic acid, curcumin, and a high-concentration ginger extract.

By reducing inflammation, FlexAgain helps alleviate joint stiffness, allowing you to move more freely.

Supports Long-Term Joint Health

FlexAgain provides commonly deficient vitamins and fatty acids, such as vitamin D3 and omega-3s, which are essential for maintaining joint health over the long run.

This comprehensive formula helps prevent joint problems from worsening while promoting overall mobility and flexibility.

Who Is FlexAgain For?

Anyone Suffering From Joint Pain

If you suffer from arthritis, sports-related joint issues, finger pain, or ankle and knee pain, this product might be what you’ve been searching for.

It’s clinically dosed with 11 effective ingredients, the most I’ve seen in any joint supplement.

Older Adults

There are so many ingredients in FlexAgain that are effective at treating joint pain that if anything natural is going to work, then this is your best bet.

It’s a comprehensive supplement that contains many ingredients for long-term joint health and immediate pain relief.

Athletes with Injuries

If you’re looking for something to support injury recovery, then this is a really good option. The fact that it’s a little bit more expensive is less of an issue if you’re looking to take it for just 3-6 months.

My Experience With FlexAgain

My journey with FlexAgain took me from trying a few joint supplements that were mildly effective to a complete believer that a natural supplement can do amazing things when it’s properly dosed.

Over the years, I’ve sampled various joint supplements, most of which had no effect or such a negligible impact that I felt like just another customer who’d squandered their money.

I regularly switch from FlexAgain to test others, which means I see how much less effective the alternatives are.

So, with FlexAgain, the daily activities we all take for granted that were previously painful are not. And while I’m sure at some point I’ll need something more substantial, for now, FlexAgain is far more effective for me than over-the-counter anti-inflammatory.

The impact of FlexAgain has been noticeable. My mobility has improved, and I don’t wake up with stiff and achy joints. As for pain relief, it’s unquestionably better.

Customer Reviews & Testimonials

Customer reviews for this premium product are outstanding, and it is rated as one of the highest-ranking joint health products on the internet.

I was scoring between 4.7 and 4.9 out of 5 stars. If you find a product that rates over 4.5 out of 5.0 stars, then you have a reasonable amount of confidence that this product has the potential to work for a lot of customers.

FlexAgain Side Effects

While FlexAgain contains natural ingredients, some users may experience side effects. I didn’t experience any adverse effects from taking it.

As with any supplement, start with the recommended dosage and discontinue use if you experience any worrying or persistent side effects.

It is also recommended that you consult your doctor beforehand, especially if you have any existing medical conditions or take other medications.

FlexAgain Alternatives

Joint Buddy

It aims to reduce joint pain and stiffness and improve mobility with ingredients like glucosamine, chondroitin, MSM, omega-3s, and anti-inflammatory herbs and vitamins.

While not quite as potent as FlexAgain, Joint Buddy provides solid value for those looking for an affordable joint support option.

Customer reviews are very positive, praising its effectiveness and reasonable price point compared to costly alternatives.

For under $30 per month, Joint Buddy offers a comprehensive formulation to help alleviate joint discomfort and promote long-term joint health.

You can read my in-depth guide in my Joint Buddy review.

Move Free

However, its formula lacks proper dosages of critical ingredients proven effective for joint pain relief.

In my experience trying Move Free, I noticed no improvement in joint discomfort or mobility despite taking it as recommended.

Customer reviews are mixed, with some praising its convenience of one pill per day, while others report no benefits. Compared to FlexAgain, Move Free falls short in delivering substantial joint relief due to its limited, underdosed ingredients.

You can read my complete Move Free review here.

Instaflex

However, the dosages of most key ingredients are too low compared to clinical recommendations. In my experience trying Instaflex for a month, I noticed no improvement in joint pain or flexibility despite its premium price point.

You can read my full Instaflex review here.

Summary

FlexAgain is the most comprehensive and effective joint health supplement I’ve tried. With its potent blend of 11 clinically backed ingredients, such as omega-3s, curcumin, glucosamine, and boswellia, dosed at optimal levels, it delivers real results for reducing joint pain, inflammation, and stiffness.

References

1. Goldberg, R. J., & Katz, J. (2007). A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain. Pain, 129(1-2), 210-223.
2. Lee, Y. H., Bae, S. C., & Song, G. G. (2012). Omega-3 polyunsaturated fatty acids and the treatment of rheumatoid arthritis: a meta-analysis. Archives of medical research, 43(5), 356-362.
3. Altman, R., & Marcussen, K. C. (2001). Effects of a ginger extract on knee pain in patients with osteoarthritis. Arthritis & Rheumatism, 44(11), 2531-2538.
4. Rondanelli, M., Fossari, F., Vecchio, V., Gasparri, C., Peroni, G., Spadaccini, D., … & Perna, S. (2020). Clinical trials on pain lowering effect of ginger: A narrative review. Phytotherapy Research, 34(11), 2843-2856.
5. Gautam, R. K., Roy, K., Thapa, G., Arora, D., Parashar, S., Gurung, B., & Deb, L. (2020). Perspective of Plant Medicine in Therapy of Rheumatoid Arthritis. Indian Journal of Pharmaceutical Sciences, 82(5).
6. Lopresti, A. L., Smith, S. J., Jackson-Michel, S., & Fairchild, T. (2022). An investigation into the effects of a curcumin extract (Curcugen®) on knee osteoarthritis pain: A randomised, double-blind, placebo-controlled study. Nutrients, 14(1), 41.
7. Shep, D., Khanwelkar, C., Gade, P., & Karad, S. (2019). Safety and efficacy of curcumin versus diclofenac in knee osteoarthritis: a randomized open-label parallel-arm study. Trials, 20, 1-11.
8. Al-Saadi, H. M., Pang, K. L., Ima-Nirwana, S., & Chin, K. Y. (2019). Multifaceted protective role of glucosamine against osteoarthritis: review of its molecular mechanisms. Scientia Pharmaceutica, 87(4), 34.
9. Runhaar, J., Rozendaal, R. M., van Middelkoop, M., Bijlsma, H. J., Doherty, M., Dziedzic, K. S., … & Zeinstra, S. B. (2017). Subgroup analyses of the effectiveness of oral glucosamine for knee and hip osteoarthritis: a systematic review and individual patient data meta-analysis from the OA trial bank. Annals of the rheumatic diseases, 76(11), 1862-1869.
10. Fransen, M., Agaliotis, M., Nairn, L., Votrubec, M., Bridgett, L., Su, S., … & LEGS Study Collaborative Group. (2015). Glucosamine and chondroitin for knee osteoarthritis: a double-blind randomised placebo-controlled clinical trial evaluating single and combination regimens. Annals of the rheumatic diseases, 74(5), 851-858.
11. Kimmatkar, N., Thawani, V., Hingorani, L., & Khiyani, R. (2003). Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee–a randomized double blind placebo controlled trial. Phytomedicine, 10(1), 3-7.
12. Yu, G., Xiang, W., Zhang, T., Zeng, L., Yang, K., & Li, J. (2020). Effectiveness of Boswellia and Boswellia extract for osteoarthritis patients: a systematic review and meta-analysis. BMC complementary medicine and therapies, 20, 1-16.
13. Brien, S., Lewith, G., Walker, A., Hicks, S. M., & Middleton, D. (2004). Bromelain as a treatment for osteoarthritis: a review of clinical studies. Evidence-based complementary and alternative medicine, 1(3), 251.
14. Rathnavelu, V., Alitheen, N. B., Sohila, S., Kanagesan, S., & Ramesh, R. (2016). Potential role of bromelain in clinical and therapeutic applications. Biomedical reports, 5(3), 283-288.
15. Brochard, S., Pontin, J., Bernay, B., Boumediene, K., Conrozier, T., & Baugé, C. (2021). The benefit of combining curcumin, bromelain and harpagophytum to reduce inflammation in osteoarthritic synovial cells. BMC Complementary Medicine and Therapies, 21, 1-17.
16. Nguyen, C., Coudeyre, E., Sellam, J., Berenbaum, F., & Rannou, F. (2024). A RANDOMIZED PLACEBO-CONTROLLED TRIAL OF ORAL RESVERATROL FOR PATIENTS WITH PAINFUL KNEE OSTEOARTHRITIS (ARTHROL). Osteoarthritis and Cartilage, 32, S51.
17. Kim, L. S., Axelrod, L. J., Howard, P., Buratovich, N., & Waters, R. F. (2006). Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial. Osteoarthritis and Cartilage, 14(3), 286-294.
18. Zhang, F. F., Driban, J. B., Lo, G. H., Price, L. L., Booth, S., Eaton, C. B., … & McAlindon, T. E. (2014). Vitamin D deficiency is associated with progression of knee osteoarthritis. The Journal of nutrition, 144(12), 2002-2008.
19. Helde-Frankling, M., & Björkhem-Bergman, L. (2017). Vitamin D in pain management. International journal of molecular sciences, 18(10), 2170.
20. Shea, M. K., & Booth, S. L. (2017). Vitamin K, osteoarthritis, and joint pain. Nutritional Modulators of Pain in the Aging Population, 225-233.
21. Maresz, K. (2021). Growing evidence of a proven mechanism shows vitamin K2 Can impact health conditions beyond bone and cardiovascular. Integrative Medicine: A Clinician’s Journal, 20(4), 34.

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