Home Fitness I Tried Focus Factor For 30 Days (My 2024 Review)
I Tried Focus Factor For 30 Days (My 2024 Review)
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I Tried Focus Factor For 30 Days (My 2024 Review)

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Ever find yourself in a mid-afternoon slump, struggling to maintain concentration? You’re not alone. In your search for answers, you’ve likely come across Focus Factor. I know I did.

Hence why I tried it for the past month to see if it was all hype.

Pros

  • This cost-effective nootropic supplement is priced better than many available.
  • It is readily available at the grocery store, so there are no shipping fees or long delivery times.

Cons

  • A low-dose proprietary blend means very few ingredients are dosed adequately to provide cognitive enhancement.

Focus Factor

Focus Factor Nootropic Brain Supplement

Proprietary blend of solid ingredients with low doses.

CHECK CURRENT DEALS
Focus Factor

What Is Focus Factor?

Focus Factor is a well-known brain health pill designed to improve aspects of mental functioning such as memory, concentration, and overall focus. But this is not their sole product, as they’ve expanded into the energy drink, energy shot, and vision enhancement markets.

I’ve had many of their Focus Factor energy drinks and was underwhelmed compared to the major players in the market. However, Focus Factor has distribution, giving them an edge over other nootropic brands as they get their old and new products into large grocery chains and Costco.

Does this make them legit?

Nooceptin Nootropic

Quick Verdict

Focus Factor Ingredients

This review will focus on the Original formula. Interestingly, Focus Factor has a proprietary blend of multiple ingredients totaling 640 mg. This already screams red flags, so I’ll estimate the dosage for each ingredient.

DMAE Bitartrate (Proven)

DMAE, chemically known as 2-(dimethylamino)ethan-1-ol, is naturally present in the human brain and certain fish. It’s a choline precursor, aiding in acetylcholine production, crucial for learning and memory [1].

Nootropics often contain DMAE as bitartrate salt. Studies show it can increase choline and acetylcholine in the brain, improving memory and attention [2][3].

Regular DMAE supplementation may enhance alertness and mood and induce lucid dreams [4][5].

It’s used in doses of 500–2000 mg daily but should be avoided during pregnancy, lactation, and by those with schizophrenia.

Since the entire Focus Factor proprietary blend is 640 mg, there is most likely very little DMAE in the formulation, potentially as low as 100-200 mg.

L-Glutamine (Speculative)

L-glutamine, an amino acid, has promising effects on endurance athletes’ cognitive function and reaction time. When added to a hydration solution, it can improve performance and quickness in reaction tests, compared to dehydration or electrolyte drinks alone [6].

Separate research indicates that glutamine supplementation can protect against cognitive impairment caused by chronic stress, suggesting its role in maintaining healthy glutamatergic neurotransmission, which is crucial for cognitive functions [7].

It appears to counteract stress-related changes in the brain, preserving synaptic health in key cognitive areas like the prefrontal cortex and hippocampus.

However, this is a rat study, so whether these functions occur within humans is uncertain. The human study used 300-500 mg of glutamine. Focus Factor contains less than 150 mg within its formula, potentially reducing its effectiveness.

Bacopa Monnieri Extract (Proven)

Bacopa monnieri is a traditional herb known for enhancing cognitive performance, particularly memory. Studies have shown that Bacopa extract improves memory formation, recall, and cognitive function, particularly bacosides A and B [8].

It has protective effects against neuronal damage and is used in treating cognitive dysfunctions like Alzheimer’s disease.

Recommended dosages for adults range from 200–400 mg daily. Bacopa is generally well-tolerated, with mild sedation or digestive issues being rare side effects.

Clinical trials indicate improved memory, attention, mood, and overall cognitive performance in the elderly [9][10][11]. However, more extensive research is needed to fully understand its efficacy across different cognitive domains.

There is little chance Focus Factor contains 200-400 mg of Bacopa since the entire formulation is only 640 mg. I’d estimate under 100 mg.

L-Pyroglutamic Acid (Speculative)

L-pyroglutamic acid is a naturally occurring amino acid found in the brain, spinal fluid, skin, and blood and is derived from glutamine. It has been shown to enhance learning and memory in studies with older rats [12].

Specifically, it aided in quicker learning and slower forgetting of tasks. These findings suggest that L-pyroglutamic acid has the potential as a nootropic substance for improving cognitive functions related to learning and memory.

However, it’s difficult to extrapolate these findings into humans.

Phosphatidylserine (Proven)

Phosphatidylserine is a key component for healthy brain function. Studies have shown that phosphatidylserine is crucial for maintaining nerve cell membranes and myelin, which is essential for effective neurotransmission [13].

As the brain ages, phosphatidylserine can help counteract cognitive decline by supporting various cognitive functions like memory formation, learning, concentration, and problem-solving [14].

It’s effectively absorbed in humans and can cross the blood-brain barrier. Phosphatidylserine supplements have been found to improve cognitive abilities and are generally well-tolerated, with dosages ranging from 100 to 800 mg per day recommended for cognitive support [15][16].

Focus Factor will have well under 100 mg of phosphatidylserine, potentially not giving you these benefits.

DHA (Proven)

Docosahexaenoic acid (DHA) is a critical component of neural membranes and plays a significant role in brain health and cognitive function.

Research shows that DHA intake, especially when combined with eicosapentaenoic acid (EPA), improves memory functions in adults [17].

This effect is particularly notable in older individuals with mild memory complaints. Higher doses of DHA and EPA (over 1 g per day) have been linked to improved episodic memory.

Observational studies also suggest a positive correlation between DHA/EPA intake and memory performance in older adults. DHA, both alone and with EPA, effectively enhances memory in aging individuals.

Since the entire proprietary blend is only 640 mg, there is not enough DHA to have a positive benefit.

Inositol (Speculative)

Inositol-stabilized arginine silicate (ASI) is an ergogenic aid known for upregulating nitric oxide, which can enhance cognitive functions.

Studies have demonstrated that ASI improves various aspects of cognitive performance, such as working memory, processing speed, and reaction time in young adults [18].

Its efficacy extends to enhancing specific cognitive domains like immediate memory.

Additionally, ASI has been shown to maintain and potentially boost reaction time, accuracy, and other cognitive functions, particularly in contexts like gaming [19].

ASI’s positive impact on mental focus and clarity has been confirmed through improvements in complex cognitive tasks that require mental flexibility and executive functioning [20].

As low as 100 mg of inositol is enough to elicit a positive cognitive response. Focus Factor can’t contain near 100 mg as it is the 7th ingredient on the list, so all ingredients above must be dosed higher.

L-Tyrosine (Proven)

L-tyrosine, an amino acid found in food, is known to boost dopamine levels in the brain. Studies have shown that L-Tyrosine supplementation can enhance cognitive control, especially in mentally demanding situations [21].

It is particularly effective in improving cognitive flexibility, an essential function influenced by dopamine. While its potential in treating clinical disorders and enhancing physical exercise is limited, L-Tyrosine is effective in short-term stressful or cognitively challenging scenarios.

Its cognitive benefits are most pronounced when neurotransmitter function is intact, but dopamine and norepinephrine levels are temporarily depleted [22].

Research indicates that effective doses for cognitive improvement start at a minimum of 2 grams. That’s over three times the entire Focus Factor formulation.

Bilberry Fruit Standardized Extract 25% Anthocyanin (Speculative)

Anthocyanin, found in red fruits and vegetables, is a phytochemical with significant health benefits, particularly for cognitive functions. It has shown promise in Alzheimer’s disease treatment by reducing oxidative stress and neuroinflammation in rodent studies [23]. Anthocyanin can protect memory, enhance cognitive abilities, and even prevent neurodegenerative processes in rodent models [24].

Studies have observed its effectiveness in reducing mental stress and improving cognitive performance [25].

Furthermore, anthocyanin-rich foods like berries are linked to improved brain function and mood in various age groups, highlighting their potential as a natural cognitive enhancer [26].

GABA (Speculative)

GABA (Gamma-aminobutyric acid) is a key inhibitory neurotransmitter in the brain, associated with reducing stress and enhancing sleep [27]. Studies have explored GABA’s effects on cognitive functions like attention and flexibility with mixed results [28].

Some research suggests that GABA supplementation can improve temporal attention, though its impact on spatial attention is less clear [29].

The effectiveness of GABA supplements for stress and sleep benefits remains uncertain, with limited evidence available [30].

Additionally, GABA’s ability to cross the blood-brain barrier and its exact mechanism of action in supplement form are still subjects of ongoing research and debate [31].

Grape Skin And Grape Seed Extract (Speculative)

Grape Skin and Grape Seed Extract (GSSE and GSE) are known for their neuroprotective effects, mainly attributed to resveratrol, a compound with antioxidant properties.

In various studies, these extracts have shown the potential to reduce brain and kidney damage, mitigate oxidative stress, and improve cognitive functions [32].

GSSE can protect against brain damage caused by high-fat diets, while GSE impacts specific brain proteins, suggesting potential benefits for cognitive disorders.

GSSE and GSE have also shown promise in modulating inflammation, tumor suppressor proteins, and neurotransmitters, offering protective effects against chemotherapeutic-induced damage [33].

Vinpocetine (Speculative)

Vinpocetine is a synthetic compound that enhances brain function by acting as a selective inhibitor of a specific enzyme, blocking sodium channels, reducing blood clotting, and improving cerebral blood flow [1].

Vinpocetine increases the brain’s glucose and oxygen consumption, thus improving tolerance to hypoxia. It also interacts with glutamate receptors and boosts ATP levels, offering neuroprotection.

Commonly used to enhance memory and treat circulatory brain disorders, it’s advised to start with a low dose (2-5 mg) to test for sensitivity, gradually increasing to 10-30 mg daily.

Side effects are rare but can include nausea and dizziness. It’s not recommended during pregnancy or lactation.

Because the efficacious dose is so small, there is likely enough in Focus Factor to see a beneficial effect.

Huperzine A (Speculative)

Huperzine A is a natural compound used as a potential treatment for Alzheimer’s disease. It acts as a reversible acetylcholinesterase inhibitor, increasing acetylcholine levels, which may enhance cognitive function [34].

Studies suggest its potential benefits in improving memory, cognitive function, and daily living activities in Alzheimer’s patients. While generally safe, more extensive trials are needed to confirm its effectiveness [35].

Huperzine A also shows promise in reducing neuroinflammation and oxidative stress after traumatic brain injury [36].

However, evidence for its efficacy in other cognitive impairments, like mild cognitive impairment and vascular dementia, is limited. Further high-quality research is necessary to establish its role in treating cognitive disorders.

The recommended dose is 1mg/kg of bodyweight and since this is near the end of the proprietary blend, I’d suspect there is less than 20 mg.

Boron (Speculative)

Boron, a trace element not yet recognized as essential for humans, has been observed to impact brain function and cognitive performance.

Studies indicate that lower boron intake can lead to decreased brain electrical activity, which is often seen in general malnutrition or heavy metal toxicity [37].

Furthermore, low boron levels are associated with poorer performance in tasks requiring manual dexterity, eye-hand coordination, attention, perception, and memory [38].

A high boron intake is considered 3.25 mg boron/2000 kcal/day within the research, which Focus Factor likely contains.

These findings suggest that boron may play a significant role in brain health and cognitive abilities.

Vanadium (Speculative)

Vanadium is a trace mineral studied for its potential role in brain health and cognitive function. However, there is limited research on its direct impact as a nootropic supplement.

Focus Factor Research

Focus Factor Review

Focus Factor has done the same playbook as Neuriva and Prevagen by conducting their own study on their formulation. Except Focus Factor never put their paper through peer review.

This lone study found Focus Factor, compared to a placebo, enhances memory, attention, concentration, and working memory in healthy adults.

After 6 weeks, subjects taking Focus Factor showed a notable increase in word recall and overall words remembered in memory tests. The improvement was significant and comparable to the cognitive performance of younger age groups.

As always, take these results with a grain of salt.

Focus Factor Price

Focus Factor and 3 main products: Original, Extra Strength, and Max Strength. There is very little difference between each. Just a 100 mg or so more in the proprietary blend. It’s hardly worth paying extra.

I’ll break down each formula by cost per serving for a one-off purchase for one bottle. Bear in mind a subscription and buying bundles discount the price.

Focus Factor Original (60 count/15 servings)Focus Factor Extra Strength (120 count/30 servings)Focus Factor MaxStrength (120 count/30 servings)
1 Bottle = $14.99 ($1/serving)1 Bottle = $39.99 ($1.33/serving)1 Bottle = $29.99 ($1/serving)
3 Bottles = $43.50 ($0.97/serving)3 Bottles = $117.57 ($1.30/serving) 
6 Bottles = $83.99 ($0.93/serving)6 Bottles = $230.39 ($1.28/serving) 

Benefits Of Focus Factor

Improves Memory, Concentration, And Focus

Many of the ingredients used in the formulation are proven to enhance memory, concentration, and focus. However, the small proprietary blend means the ingredients aren’t dosed appropriately to give you these brain benefits.

Instead, you’re taking a glorified multi-vitamin with potential brain-boosting effects.

Readily Available At The Grocery Store

You’ll find Focus Factor in the aisle next to Prevagen and Neuriva, where you can pick it up on your regular grocery run.

It means you save on shipping and delivery times.

My Experience With Focus Factor

Is Focus Factor Legit

I’m always game to give nootropics a try. I’ve had good and bad experiences with many, and it heavily depends on the ingredients and doses. Focus Factor didn’t provide me with any brain-boosting benefits.

I didn’t feel more dialed in when writing this review and haven’t noticed any differences in the past few weeks of taking it.

I’m underwhelmed by the formula, and after digesting the ingredients list and total dose, I understand why I didn’t see any benefit from it.

Focus Factor Side Effects

Based on their internal study, Focus Factor was well-tolerated, with fewer adverse effects reported compared to the placebo group. I personally didn’t experience any negative side effects when taking it.

Before starting any new supplement, seek advice from a healthcare professional, particularly if you have existing health conditions or are pregnant or breastfeeding.

User Reviews & Testimonials

Despite the formulation, Focus Factor has some raving reviews. Here’s a sample:

My husband has been using Focus Factor for at least five years now. This supplement has made his thinking quicker and more focused, along with having more energy. I would definitely recommend this product to everyone.” – Laurie H.

Not everything is positive though:

“Nothing! I can see no effects after 30 days of use. Having to take 4 large pills daily seems like a gimmick more than anything. I will continue to take this supplement for another 30 days. I am going to return the unused pills if I don’t see any results.” – Richard B.

Focus Factor Alternatives

I would look at alternatives to Focus Factor that may give you better cognitive enhancing effects. Here are my recommendations.

Braini

Braini

Braini stands apart by being stimulant-free, giving rapid effects, and having a limited ingredient list focused on long-term cognitive gains. However, it does not provide the rapid euphoric boost that some users may expect from a brain supplement.

Key ingredients in Braini include Peptylin, a silk protein peptide with neuroprotective effects and potential benefits for executive function; NeurXcel, which is high in omega fatty acids; and Wild Canadian Blueberry extract, which is known for its antioxidant properties and cognitive support.

Clinical trials support Braini, backed by a 60-day money-back guarantee and a 30-day challenge to scientifically measure gains in brain function.

Our in-depth breakdown can be found in our Braini review.

NooCube

NooCube

NooCube is a popular brain-boosting supplement due to its claimed quick cognitive effects. Bacopa Monnieri, L-Tyrosine, and L-Theanine are among the components of NooCube.

These are well-known for their psychological benefits. Some, such as Huperzine-A and Alpha GPC, remain speculative in the absence of more research.

NooCube is designed to boost cognition and alertness without using stimulants, and each ingredient’s amount is openly listed.

NooCube is notably beneficial for working professionals, students, seniors, gamers, and combat athletes since it provides various cognitive benefits without the jittery side effects associated with caffeine.

Our in-depth breakdown can be found in our NooCube review.

Mind Lab Pro

Mind Lab Pro

Mind Lab Pro is a well-known nootropic that has grown in popularity due to its purported cognitive benefits.

Its formulation is designed to increase mental clarity and focus and is built of natural ingredients. It’s stimulant-free, making it a good choice for anyone looking for a balanced regimen.

Its distinct blend of 11 research-backed ingredients sets it apart from competitors in the brain health supplement industry. These substances have been selected with care to aid cognitive processes such as memory, focus, mental clarity, mood, and cognitive processing speed.

Despite some criticism about the dosage of certain ingredients and the need for more scientific evidence, Mind Lab Pro has received widespread praise for its capacity to increase cognitive performance, particularly in professionals, students, the elderly, and athletes.

Our Mind Lab Pro review contains an in-depth breakdown.

Vyvamind

Vyvamind

Vyvamind is a nootropic containing caffeine and L-theanine to assist with focus and cognitive performance. Users report improved attention, energy levels, and cognitive ability without experiencing any major crashes.

Vyvamind’s formulation, which includes L-tyrosine and citicoline in lower levels than some studies suggest, intends to supplement the primary nootropic duo of caffeine and L-theanine.

This combo is well-known for improving focus and cognitive function. The supplement is marketed as an alternative to high-stimulant choices, appealing to customers looking for a more natural and less intense approach to cognitive development.

Vyvamind is appropriate for coffee-averse individuals, busy professionals needing a focus boost, and students during study sessions.

Our Vyvamind review contains an in-depth breakdown and is ranked the best nootropic for energy.

Frequently Asked Focus Factor Questions

Can Focus Factor Supplements Improve Cognitive Function?

While Focus Factor contains cognitive-enhancing ingredients, they are likely underdosed and won’t provide brain-boosting effects.

Are There Supplements For Children’s Brain Health?

Focus Factor Kids is specifically formulated to support children’s brain health and cognitive function.

How Does Prevagen Differ From Focus Factor?

Prevagen contains a unique ingredient called apoaequorin, which is different from the blend of vitamins and nutrients found in Focus Factor products.

Conclusion

There are better options for cognitive enhancing nootropics than Focus Factor. Unfortunately, the low-dose proprietary blend means you’re getting an underdosed formulation unlikely to boost brain power.

Focus Factor

Focus Factor Nootropic Brain Supplement

Proprietary blend of solid ingredients with low doses.

CHECK CURRENT DEALS
Focus Factor

References

  1. Malík, M., & Tlustoš, P. (2022). Nootropics as cognitive enhancers: types, dosage and side effects of smart drugs. Nutrients, 14(16), 3367.
  2. Malanga, G., Belen Aguiar, M., D Martinez, H., & Puntarulo, S. (2012). New insights on dimethylaminoethanol (DMAE) features as a free radical scavenger. Drug metabolism letters, 6(1), 54-59.
  3. Blin, O., Audebert, C., Pitel, S., Kaladjian, A., Casse-Perrot, C., Zaim, M., … & Marien, M. (2009). Effects of dimethylaminoethanol pyroglutamate (DMAE p-Glu) against memory deficits induced by scopolamine: evidence from preclinical and clinical studies. Psychopharmacology, 207, 201-212.
  4. Dimpfel, W., Wedekind, W., & Keplinger, I. (2003). Efficacy of dimethylaminoethanol (DMAE) containing vitamin-mineral drug combination on EEG patterns in the presence of different emotional states. European journal of medical research, 8(5), 183-191.
  5. Sergio, W. (1988). Use of DMAE (2-dimethylaminoethanol) in the induction of lucid dreams. Medical hypotheses, 26(4), 255-257.
  6. Pruna, G. J., Hoffman, J. R., McCormack, W. P., Jajtner, A. R., Townsend, J. R., Bohner, J. D., … & Fukuda, D. H. (2016). Effect of acute L-Alanyl-L-Glutamine and electrolyte ingestion on cognitive function and reaction time following endurance exercise. European Journal of Sport Science, 16(1), 72-79.
  7. Baek, J. H., Jung, S., Son, H., Kang, J. S., & Kim, H. J. (2020). Glutamine supplementation prevents chronic stress-induced mild cognitive impairment. Nutrients, 12(4), 910.
  8. Singh, H. K., & Dhawan, B. N. (1997). NEUROPSYCHOPHARMACOLOGICAL EFFECTS OF THE AYURVEDIC NOOTROPlC BACOPA MONNlERA LINN.(BRAHMI). Indian Journal of Pharmacology, 29(5), 359-365.
  9. Calabrese, C., Gregory, W. L., Leo, M., Kraemer, D., Bone, K., & Oken, B. (2008). Effects of a standardized Bacopa monnieri extract on cognitive performance, anxiety, and depression in the elderly: a randomized, double-blind, placebo-controlled trial. The journal of alternative and complementary medicine, 14(6), 707-713.
  10. Kongkeaw, C., Dilokthornsakul, P., Thanarangsarit, P., Limpeanchob, N., & Scholfield, C. N. (2014). Meta-analysis of randomized controlled trials on cognitive effects of Bacopa monnieri extract. Journal of ethnopharmacology, 151(1), 528-535.
  11. Pase, M. P., Kean, J., Sarris, J., Neale, C., Scholey, A. B., & Stough, C. (2012). The cognitive-enhancing effects of Bacopa monnieri: a systematic review of randomized, controlled human clinical trials. The Journal of Alternative and Complementary Medicine, 18(7), 647-652.
  12. Silva, A. R., Silva, C. G., Ruschel, C., Helegda, C., Wyse, A. T. S., Wannmacher, C. M. D., … & Dutra-Filho, C. S. (2001). L-pyroglutamic acid inhibits energy production and lipid synthesis in cerebral cortex of young rats in vitro. Neurochemical research, 26, 1277-1283.
  13. Glade, M. J., & Smith, K. (2015). Phosphatidylserine and the human brain. Nutrition, 31(6), 781-786.
  14. Cenacchi, T., Bertoldin, T., Farina, C., Fiori, M. G., Crepaldi, G., Azzini, C. F., … & Allegro, L. (1993). Cognitive decline in the elderly: a double-blind, placebo-controlled multicenter study on efficacy of phosphatidylserine administration. Aging Clinical and Experimental Research, 5, 123-133.
  15. Kang, E. Y., Cui, F., Kim, H. K., Nawaz, H., Kang, S., Kim, H., … & Go, G. W. (2022). Effect of phosphatidylserine on cognitive function in the elderly: A systematic review and meta-analysis. ????????, 54(1), 52-58.
  16. Ma, X., Li, X., Wang, W., Zhang, M., Yang, B., & Miao, Z. (2022). Phosphatidylserine, inflammation, and central nervous system diseases. Frontiers in Aging Neuroscience, 14, 975176.
  17. Yurko-Mauro, K., Alexander, D. D., & Van Elswyk, M. E. (2015). Docosahexaenoic acid and adult memory: a systematic review and meta-analysis. PloS one, 10(3), e0120391.
  18. Gills, J. L., Campitelli, A., Jones, M., Paulson, S., Myers, J. R., Madero, E. N., … & Gray, M. (2021). Acute inositol-stabilized arginine silicate improves cognitive outcomes in healthy adults. Nutrients, 13(12), 4272.
  19. Sowinski, R., Gonzalez, D., Xing, D., Yoo, C., Jenkins, V., Nottingham, K., … & Kreider, R. B. (2021). Effects of inositol-enhanced bonded arginine silicate ingestion on cognitive and executive function in gamers. Nutrients, 13(11), 3758.
  20. Kalman, D., Harvey, P. D., Perez Ojalvo, S., & Komorowski, J. (2016). Randomized prospective double-blind studies to evaluate the cognitive effects of inositol-stabilized arginine silicate in healthy physically active adults. Nutrients, 8(11), 736.
  21. Steenbergen, L., Sellaro, R., Hommel, B., & Colzato, L. S. (2015). Tyrosine promotes cognitive flexibility: evidence from proactive vs. reactive control during task switching performance. Neuropsychologia, 69, 50-55.
  22. Jongkees, B. J., Hommel, B., Kühn, S., & Colzato, L. S. (2015). Effect of tyrosine supplementation on clinical and healthy populations under stress or cognitive demands—A review. Journal of psychiatric research, 70, 50-57.
  23. Suresh, S., Begum, R. F., Singh, A., & Chitra, V. (2022). Anthocyanin as a therapeutic in Alzheimer’s disease: A systematic review of preclinical evidences. Ageing Research Reviews, 76, 101595.
  24. Carvalho, F. B., Gutierres, J. M., Bueno, A., Agostinho, P., Zago, A. M., Vieira, J., … & Andrade, C. M. (2017). Anthocyanins control neuroinflammation and consequent memory dysfunction in mice exposed to lipopolysaccharide. Molecular Neurobiology, 54, 3350-3367.
  25. Bonyadi, N., Dolatkhah, N., Salekzamani, Y., & Hashemian, M. (2022). Effect of berry-based supplements and foods on cognitive function: A systematic review. Scientific reports, 12(1), 3239.
  26. Travica, N., D’Cunha, N. M., Naumovski, N., Kent, K., Mellor, D. D., Firth, J., … & Marx, W. (2020). The effect of blueberry interventions on cognitive performance and mood: A systematic review of randomized controlled trials. Brain, behavior, and immunity, 85, 96-105.
  27. Van Hout, M. C. (2018). A narrative review of the naturally occurring inhibitory neurotransmitter gamma-aminobutyric acid (GABA) called phenibut in dietary supplements. Performance enhancement & health, 6(1), 33-35.
  28. Lim, L. W., & Aquili, L. (2021). GABA supplementation negatively affects cognitive flexibility independent of tyrosine. Journal of Clinical Medicine, 10(9), 1807.
  29. Leonte, A., Colzato, L. S., Steenbergen, L., Hommel, B., & Akyürek, E. G. (2018). Supplementation of gamma-aminobutyric acid (GABA) affects temporal, but not spatial visual attention. Brain and cognition, 120, 8-16.
  30. Hepsomali, P., Groeger, J. A., Nishihira, J., & Scholey, A. (2020). Effects of oral gamma-aminobutyric acid (GABA) administration on stress and sleep in humans: A systematic review. Frontiers in neuroscience, 14, 923.
  31. Boonstra, E., De Kleijn, R., Colzato, L. S., Alkemade, A., Forstmann, B. U., & Nieuwenhuis, S. (2015). Neurotransmitters as food supplements: the effects of GABA on brain and behavior. Frontiers in psychology, 1520.
  32. Sochorova, L., Prusova, B., Cebova, M., Jurikova, T., Mlcek, J., Adamkova, A., … & Sochor, J. (2020). Health effects of grape seed and skin extracts and their influence on biochemical markers. Molecules, 25(22), 5311.
  33. El Gengaihi, S., & Abou Baker, D. H. (2017). Grape seeds extract as brain food: a review. International Journal of Pharmaceutical and Clinical Research, 9(1), 77-85.
  34. Li, J., Wu, H. M., Zhou, R. L., Liu, G. J., & Dong, B. R. (2008). Huperzine A for Alzheimer’s disease. Cochrane Database of Systematic Reviews, (2).
  35. Ghassab?Abdollahi, N., Mobasseri, K., Dehghani Ahmadabad, A., Nadrian, H., & Mirghafourvand, M. (2021). The effects of Huperzine A on dementia and mild cognitive impairment: An overview of systematic reviews. Phytotherapy Research, 35(9), 4971-4987.
  36. Mei, Z., Zheng, P., Tan, X., Wang, Y., & Situ, B. (2017). Huperzine A alleviates neuroinflammation, oxidative stress and improves cognitive function after repetitive traumatic brain injury. Metabolic Brain Disease, 32, 1861-1869.
  37. Penland, J. G. (1994). Dietary boron, brain function, and cognitive performance. Environmental health perspectives, 102(suppl 7), 65-72.
  38. Penland, J. G. (1998). The importance of boron nutrition for brain and psychological function. Biological trace element research, 66, 299-317.

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James de Lacey James is a professional strength & conditioning coach that works with professional and international level teams and athletes. He owns Sweet Science of Fighting, is a published scientific researcher and has completed his Masters in Sport & Exercise Science. He's combined my knowledge of research and experience to bring you the most practical bites to be applied to your combat training.