If you’ve been around training long enough, you’ve probably noticed that your energy and recovery don’t just depend on caffeine or sleep. There’s another layer, the one that determines how well your cells actually make energy, repair themselves, and keep you performing when life’s hectic. That’s where NAD+ comes in.
Qualia NAD+ is one of the more advanced supplements built around that idea. Instead of just throwing a single NAD+ precursor into a capsule, Neurohacker Collective took a systems-level approach.
It’s designed to raise NAD+, support mitochondria, and promote cleaner cellular energy rather than the short-lived buzz you get from stimulants.
I’ve tested several NAD+ products over the years, from straightforward NR formulas to liposomal NAD+ liquids, and recently ran Qualia NAD+ for two months to see how it holds up.
The goal was simple: does it genuinely move the needle on daily energy, recovery, and mental clarity, or is it just another expensive capsule with good marketing?
Quick Verdict
Qualia NAD+ is one of those formulas that clearly wasn’t built overnight. It combines 300 mg of NIAGEN, a clinically supported dose for raising NAD+, with smaller amounts of niacinamide, niacin, resveratrol, and mineral cofactors.
There’s also a touch of caffeine from coffee fruit extract and some theanine to smooth it out. In short, it’s a multi-pathway NAD+ booster, not just a one-ingredient capsule.
In practice, it feels more like a foundation than a quick energy fix. The difference builds gradually, and it’s not something you “feel” on day one. Over a few weeks, you notice that your energy dips aren’t as deep and your focus lasts longer.
However, at $69 per bottle, it’s on the higher end of the NAD+ category, and the small caffeine dose might turn off those who prefer fully stimulant-free supplements.
For most guys, I’d say NooCube NAD+ offers better value and a cleaner profile if your main goal is simply to raise NAD+ efficiently.
But if you appreciate a systems-based formula and don’t mind paying a bit more, Qualia NAD+ delivers a well-rounded, intelligently designed approach.
Pros
- Clinically dosed NIAGEN (NR 300 mg): matches human studies showing real NAD+ increases.
- Comprehensive design: combines NR with niacinamide, niacin, resveratrol, minerals, and B-vitamins for full pathway support.
- Noticeably smoother energy: mild 28 mg caffeine paired with theanine gives focus without jitters.
- High manufacturing quality: transparent labeling, reputable brand, and consistent user feedback.
- System-based formula: supports mitochondrial function, sirtuins, and cell repair rather than chasing quick stimulation.
Cons
- Expensive: $69 per bottle or $59 on subscription, which adds up for long-term use.
- Contains caffeine: small dose, but not ideal if you’re avoiding stimulants.
- Modest resveratrol (50 mg): lower than doses used in most sirtuin studies.
- Subtle effects: benefits build gradually over weeks, not a product you “feel” overnight.
What Is Qualia NAD+
Qualia NAD+ is Neurohacker Collective’s take on cellular energy optimization. It’s a supplement designed to elevate NAD+ levels, support mitochondrial health, and enhance recovery and focus at the cellular level rather than through heavy stimulation.
It’s built on the premise that when NAD+ declines (which happens naturally with age, stress, poor sleep, or overtraining), our energy metabolism, repair processes, and mental clarity all take a hit.
Where most NAD+ supplements rely on a single ingredient, usually NMN or NR, Qualia NAD+ uses a multi-pathway approach. The formula combines NIAGEN (nicotinamide riboside, 300 mg) with smaller amounts of niacinamide and niacin, effectively targeting several routes of NAD+ synthesis.
The addition of resveratrol helps activate sirtuins, the enzymes that depend on NAD+ for cellular repair and longevity. There’s also Aquamin, a trace mineral blend for electrolyte balance and enzyme function, and a light coffeeberry extract that adds 28 mg of natural caffeine for smoother alertness, balanced by the calming effect of L-theanine.
In simpler terms, Qualia NAD+ aims to help your body do three things better:
- Rebuild NAD+ stores through clinically backed precursors.
- Support mitochondrial energy production for steady physical and mental performance.
- Enhance long-term cell maintenance by activating repair enzymes and reducing oxidative stress.
It’s part of Neurohacker’s larger “Qualia” lineup, known for complex, research-heavy formulations that prioritize synergy over simplicity.
This approach isn’t for everyone, but it’s appealing if you’re the type who wants every piece of the metabolic puzzle covered rather than just one.
Qualia NAD+ Ingredients
Qualia NAD+ takes a layered approach to NAD+ support by combining a clinically strong dose of nicotinamide riboside (NR) with a mix of cofactors, vitamins, and plant compounds that complement the NAD+ pathway. It’s not a simple “one ingredient” formula. Instead, it’s designed to hit multiple steps of the process that drives energy, repair, and resilience.
Nicotinamide Riboside (NIAGEN) — 300 mg
This is the backbone of the product. NR is a direct NAD+ precursor and one of the few forms of vitamin B3 proven in human studies to raise NAD+ levels.
Clinical trials using 250–1000 mg/day consistently show measurable increases in whole-blood NAD+, sometimes as high as 40–60% within a few weeks. The 300 mg used here sits squarely in that effective range — not underdosed, not excessive.
What you can expect from this: not a stimulant hit, but better baseline energy, faster recovery after hard training, and sharper mental clarity when used consistently for a few weeks. NR makes you feel restored, rather than wired.
Niacinamide and Niacin — 254 mg total (niacinamide + niacin)
These are alternate forms of vitamin B3, included to support NAD+ production through complementary pathways. The niacinamide component works quietly to sustain NAD+ without causing flushing, while niacin feeds the traditional NAD salvage pathway.
The amount of actual niacin here is low enough to avoid the uncomfortable “flush” but still meaningful for metabolism support.
Trans-Resveratrol — 50 mg
Resveratrol is a polyphenol that can activate sirtuins, the same longevity-related enzymes that depend on NAD+. It’s also a strong antioxidant, helping reduce oxidative stress and inflammation.
However, most studies on sirtuin activation use 150–1000 mg per day, so the 50 mg here is modest, likely more for antioxidant synergy than a major longevity driver on its own.
Organic Coffeeberry Whole Coffee Fruit Extract — 40 mg (?28 mg caffeine)
This adds a very small, natural caffeine dose, roughly equal to one-third of a cup of coffee, intended to provide smoother alertness.
Aquamin (Magnesium Hydroxide and Trace Minerals) — 150 mg
Aquamin is derived from marine minerals and provides magnesium plus over 70 trace elements. Magnesium plays a role in hundreds of enzymatic processes, including energy production and mitochondrial function. While 150 mg isn’t a full daily dose, it’s a good supportive amount that complements the NAD+ pathway.
B-Vitamin Complex from S. cerevisiae Culture
This yeast-based complex provides thiamine, riboflavin, vitamin B6, folate, B12, biotin, and pantothenic acid, all at modest levels. These vitamins act as cofactors in the metabolic and methylation pathways that convert nutrients into usable energy. While the doses aren’t high enough to correct deficiencies, they ensure no bottlenecks in the energy cycle.
Qualia NAD+ Price
Qualia NAD+ is priced firmly in the premium range, which is no surprise, given Neurohacker’s reputation for overbuilding their formulas. Here’s how it breaks down:
| Option | Price | Details |
| One-time purchase | $69 | 30 servings (1 month supply) |
| Subscription | $59 | First shipment $29, renews monthly |
There are occasional discounts for first-time buyers, but the monthly commitment still puts it among the higher-end NAD+ supplements on the market.
Benefits of Qualia NAD+
Steadier, All-Day Energy
The biggest difference most people feel after a couple of weeks is a steady and more sustained energy levels throughout the day. By raising NAD+ levels, Qualia NAD+ helps your mitochondria produce ATP more efficiently, giving you a smoother, more reliable energy curve throughout the day.
For me, that translated into longer, more focused work sessions and better concentration during evening training sessions. It’s not like flipping a switch, it’s more like your internal battery now charges to 100% instead of 80%.
This kind of energy stability is especially noticeable for men in their 30s and 40s who train hard, work full days, and burn the candle at both ends. It helps you stay in the zone longer without leaning on constant caffeine refills.
Cognitive Focus and Mental Endurance
Between the mild caffeine and L-theanine, there’s a noticeable improvement in focus and composure, especially during long hours of concentrated work. The pair is well-studied — caffeine boosts alertness, theanine smooths it out, and together they improve attention and reaction time without jitter.
The NAD+ and resveratrol side of the formula add a deeper layer here: supporting neuronal energy metabolism and reducing oxidative stress. Over a few weeks, that can make you feel mentally “fresher”, less foggy, and more stable.
If you’re used to feeling mentally drained after work or coaching sessions, this is the area where Qualia NAD+ starts earning its keep.
Better Recovery and Resilience
Raising NAD+ levels helps you both to push harder and to bounce back faster. NAD+ plays a central role in DNA repair and cellular recovery, which affects everything from muscle tissue repair to how well you handle inflammation and stress.
After about three weeks of daily use, I noticed that post-training soreness didn’t linger as long, and I could handle higher total volume before hitting that “overreached” fatigue. It doesn’t replace sleep, but it does help your body make better use of whatever recovery you get.
Long-Term Cellular Health and “Aging from the Inside Out”
This is the slower, deeper side of NAD+ supplementation. Resveratrol, niacinamide, and NR all feed into sirtuin activity, oxidative balance, and mitochondrial biogenesis — the cellular processes linked to longevity and metabolic health.
At 50 mg of resveratrol, Qualia NAD+ isn’t a hardcore longevity supplement, but it contributes to the bigger picture. Over months, maintaining higher NAD+ levels can mean better stress tolerance, fewer energy crashes, and potentially slower cellular aging markers.
It’s not a magic bullet, but for men who care about aging like an athlete instead of just getting older, this kind of background support matters.
Who Is Qualia NAD+ For?
Men in Their 30s and 40s Feeling the “Energy Dip”
If you’ve started noticing that your baseline energy isn’t what it used to be, even with decent sleep and nutrition, this is exactly the scenario NAD+ supplementation was built for. Around your mid-30s, NAD+ levels begin to decline naturally, and that drop affects how efficiently your cells produce energy.
Qualia NAD+ helps refill that tank. It doesn’t mask fatigue; it supports the systems that create energy in the first place. You won’t suddenly feel twenty again, but you’ll likely find your stamina, mental sharpness, and recovery trending in the right direction after a few consistent weeks.
Busy Professionals Balancing Work, Training, and Family
This is the group I personally fall into with early mornings, full workdays, training sessions, and family time at night. There’s no room for crashes or sluggish afternoons.
The combination of NAD+ support and low-dose caffeine/theanine helps keep performance steady through long, unpredictable days.
If your routine demands focus under fatigue, this formula can make that grind feel more sustainable. It’s energy that feels clean, not forced.
Lifters, Fighters, and Weekend Athletes Focused on Recovery
If you train with intensity, heavy lifting, grappling, CrossFit, or even long endurance sessions, recovery is where you win or lose. NAD+ plays a role in mitochondrial repair and inflammation control, which are essential for bouncing back faster between sessions.
I found Qualia NAD+ helped take the edge off the deep fatigue that can build after multiple hard days in a row. It won’t turn you into a machine, but it helps smooth the valleys between sessions so you can show up more consistently.
Who It’s Not For
If you’re expecting a stimulant-style kick, this isn’t your supplement. The energy here builds quietly, noticeable only when you stop running on fumes.
It’s also not ideal for men who want a completely caffeine-free stack, since there’s about 28 mg of caffeine in each serving. And if you’re on a tight budget, you can get 80–90% of the NAD+ benefits from NooCube NAD+ at a lower cost.
In short, Qualia NAD+ is for men who are already doing the fundamentals and want to squeeze out a little more performance and resilience from their system.
If you’re still skipping sleep and living on coffee, it’s not going to save you. But if you’re dialed in, it can help you run that system more efficiently.
My Experience Taking Qualia NAD+
I ran Qualia NAD+ for two full months at two capsules every morning with breakfast. My schedule during that time was packed: early mornings, four lifting sessions a week, two grappling days, client work, filming and editing content, and family life with two small kids.
That combination usually drains me by Thursday, so anything claiming to improve recovery and energy balance gets a fair test in my world.
The first couple of weeks were quiet, which I expected. NAD+ boosters take time to build up. Still, I noticed my mornings felt a little smoother.
The mild caffeine from coffeeberry gave a gentle lift, but without the crash or jitter. By week two, I was skipping my usual second coffee, which was the first sign something was shifting under the hood.
Around week three, the difference became clearer. I was recovering faster and staying sharper longer. The kind of mental fatigue that usually sets in late afternoon showed up later, and post-training soreness seemed to resolve faster. My sleep also felt a touch deeper, which I suspect came from being less wired during the day.
When I stopped for a few days, I felt the difference immediately: heavier mornings, slower focus, and the return of that familiar mid-afternoon drag. That contrast convinced me it wasn’t placebo, the product was quietly improving baseline function.
The main negative is the price and the fact that it’s not fully stimulant-free. I like to cycle off caffeine sometimes, and this product doesn’t let you do that unless you pause it completely.
The resveratrol dose could also be higher, as 50 mg is fine for general support, but below what most sirtuin studies use. Still, it’s a well-rounded, well-tolerated formula. No flushing, no GI upset, no sleep interference.
Qualia NAD+ is the kind of supplement you notice most when you stop taking it. For long days, hard training, and everything in between, it felt like my system was running a little cleaner and recharging a little faster.
Qualia NAD+ Customer Reviews & Testimonials
To balance my own impressions, I dug into what other users were saying about Qualia NAD+, both on Neurohacker’s website and in third-party reviews.
The general sentiment lines up with my experience: most users describe steady, noticeable improvements in energy and focus after a few weeks, rather than any instant “wow” effect.
On Neurohacker’s official site, the product sits at around 4.5 out of 5 stars from hundreds of verified reviews. People often mention words like “clean energy,” “clarity,” and “focus without the crash.”
A common theme is that it takes time, and the benefits build gradually but feel more stable than with caffeine or pre-workout supplements.
One user wrote:
“I started noticing improvements within about two weeks — more mental energy and less fatigue in the afternoons. I’ve tried NMN and other NAD boosters, but this one feels more complete.”
— Ed W., June 2025
Another said:
“Pure energy and mental focus. It’s not like a coffee rush. More like my brain’s just running more efficiently.”
— Victoria D., June 2025
Some reviewers even commented on skin quality and overall vitality, which makes sense given NAD+’s role in cellular repair:
“After two weeks my skin looked healthier and I just felt more awake in general. Small changes, but they add up.”
— Victoria D.
Of course, not every review is glowing. A few users mention that they didn’t feel much difference or found the price hard to justify for subtle results.
One user noted that it “took nearly a month to feel anything,” which aligns with how long NAD+ levels usually take to build up in the body.
Overall, the reviews paint a consistent picture: steady energy, smoother focus, better recovery, but not a “feel-it-right-away” supplement. The effects seem to compound with daily use.
Side Effects
One of the nice things about Qualia NAD+ is how cleanly it runs. During my two-month test, I didn’t experience any side effects at all.
And that seems to be the general consensus among other users too. The formula is well-tolerated because it’s built around NR (nicotinamide riboside), which has one of the best safety profiles among NAD+ precursors.
That said, there are still a few things worth knowing before jumping in.
The first is caffeine sensitivity. Even though the dose is small at about 28 mg per serving, or roughly a third of a cup of coffee, it’s enough to matter if you’re stacking it with other caffeinated products like pre-workouts or morning coffee.
A second potential issue is niacin warmth or flushing. The formula includes a bit of niacin and niacinamide alongside NR to support multiple NAD+ pathways.
It’s a smart design, but if you’re very sensitive to niacin, you might feel a slight warmth or tingle after taking it. It’s mild and short-lived for most people and nothing like the high-dose flush from standalone niacin supplements.
Finally, as with any NAD+ booster, some users report mild digestive discomfort during the first few days. That usually passes once the body adapts. Taking it with food, as recommended, helps avoid that completely.
Overall, Qualia NAD+ is a low-risk supplement with a strong safety record. Neurohacker is transparent with dosing, and nothing in the formula pushes into risky or experimental territory.
Qualia NAD+ Alternatives
NooCube NAD+
If you want a product that simply raises NAD+ efficiently without the extras, NooCube NAD+ is the one to start with. It’s built around nicotinamide riboside (NR), which is the same clinically proven precursor used in Qualia, but without caffeine, resveratrol, or mineral blends.
That simplicity makes it cheaper and cleaner, especially if your goal is straightforward NAD+ elevation and you’re already covering your B-vitamin bases elsewhere.
It uses the same daily 300 mg NR dose, meaning you’ll still see similar increases in NAD+ levels after a few weeks, but at a lower monthly cost.
In my experience, NooCube felt neutral, smooth, and dependable, making it ideal for men who prefer a supplement that quietly supports recovery and daily energy without adding any stimulation. It’s not as complex or “biohacker-oriented” as Qualia, but in terms of effectiveness per dollar, it’s hard to beat.
You can read my NooCube NAD+ review for my experience.
Aeon NAD+
Aeon NAD+ takes a different approach and aims at whole-cell longevity. The formula combines NMN and NR (as Nicotinamide DUO) with a lineup of polyphenols like resveratrol, quercetin, EGCG, fisetin, and astragalus, plus longevity compounds like TMG, spermidine, and piperine to enhance absorption.
During my testing, Aeon delivered a more gradual, full-body effect like steadier energy, better recovery, and an overall “sharper baseline.”
It didn’t have the mild lift that Qualia gives (since it’s caffeine-free), but after 3–4 weeks, I could tell my system was running smoother, especially on high training volume weeks.
Aeon feels more like a daily health and repair formula than a productivity enhancer. It’s also slightly more affordable for the ingredient range it covers.
The trade-off is that some doses are lower than clinical standards, and the effects take longer to build. But as a long-term NAD+ and longevity stack, it’s one of the most complete products I’ve used.
You can read my Aeon NAD+ review for my experience.
Rho NAD+
Then there’s Rho NAD+, which takes a completely different route: instead of giving you precursors like NR or NMN, it delivers NAD+ directly in a liposomal liquid.
The claim is that the liposomes help the NAD+ survive digestion and reach cells faster.
When I tested it, I actually did feel a subtle clarity boost within the first week, something you usually don’t get from capsule-based precursors that need to convert over time.
The effects were clean but short-lived; after about two weeks, I stopped noticing much of a difference. The taste wasn’t great either, but it was easy to take.
The bigger issue is scientific support. Direct oral NAD+ has much weaker evidence than NR or NMN when it comes to reliably increasing NAD+ inside cells. It might still help if your digestion is compromised or you dislike pills, but it’s not the most efficient route.
You can read my Rho NAD+ review for my experience.
Frequently Asked Qualia NAD+ Questions
Can I take Qualia NAD+ with other supplements?
Yes, in fact, it stacks well with most performance and recovery staples. You can safely combine it with creatine, omega-3s, vitamin D, zinc, magnesium, or a protein supplement without issue.
NAD+ precursors like NR operate at the cellular level, so they don’t interfere with most other nutrients or ergogenics.
The only caution is caffeine overlap. Each serving of Qualia NAD+ has about 28 mg of caffeine from coffee fruit extract. That’s mild, but if you’re already running a pre-workout or drinking a few cups of coffee, it can add up. For stimulant-sensitive guys, it’s better to take it on an empty caffeine day or in place of your first coffee.
What’s the best time to take Qualia NAD+?
Morning, with food.
That’s the easiest way to integrate it and minimize any mild stomach discomfort. NAD+ production is tied to circadian rhythm, so taking it early in the day supports the body’s natural cycle of energy and repair. You’ll also avoid potential sleep disruption from the small caffeine dose.
Consistency matters more than timing, though. Take it daily, ideally for at least 8–12 weeks, since NAD+ levels build gradually.
Is Qualia NAD+ worth the $69 monthly cost?
It depends on what you’re looking for.
If you want the cleanest, most comprehensive NAD+ formula that covers multiple pathways and adds supportive cofactors for brain function and cellular repair, then yes, Qualia NAD+ earns its price. It’s intelligently designed, clinically dosed, and backed by a trustworthy company.
But if your goal is simply to raise NAD+ efficiently, there’s no question that NooCube NAD+ gives you similar results for less money.
Does Qualia NAD+ cause any side effects?
For most users, no. It’s a low-risk supplement with an excellent safety record. The worst you might experience is mild stimulation (from the caffeine) or a bit of niacin warmth shortly after taking it. Both are harmless and usually short-lived.
Take it with food, drink enough water, and you’ll almost certainly avoid any issues. If you’re highly sensitive to caffeine or already take multiple energizing supplements, it’s smart to test tolerance by starting with one capsule for the first few days.
Summary
Qualia NAD+ is what happens when a supplement company decides to engineer an NAD+ formula from every angle instead of taking shortcuts.
It combines a clinically dosed 300 mg of NIAGEN (nicotinamide riboside) with supporting ingredients like niacinamide, niacin, resveratrol, Aquaminminerals, and B vitamins, all designed to raise NAD+ levels and keep your energy production machinery running efficiently.
In my two-month test, it gave me a steady foundation. Energy became more reliable, recovery quicker, and focus sharper throughout the day.
It’s the kind of improvement you notice most when you stop taking it: your energy dips return, and your system feels less efficient. That tells me it’s doing something real.
Still, it’s not for everyone. The price is high and the small caffeine content keeps it from being a truly stimulant-free stack. And while the resveratrol dose could be higher, the overall design and ingredient quality make it one of the more thoughtful NAD+ products out there.
If you want a simple, budget-friendly option that still delivers strong NAD+ support, NooCube NAD+ remains the better starting point. It’s clean, affordable, and clinically effective.
But if you’re after a premium, systems-based approach that supports both performance and long-term cellular health, Qualia NAD+ earns its place.
Best NAD+ Supplement
NooCube NAD+
A powerful NAD+ supplement using NR for rapid absorption with 250 mg per serving for easy individualization.
CHECK CURRENT DEALS
