I Tried The Best NAD+ Supplements (2025)

Ever wondered how to boost your energy levels and enhance your overall well-being? NAD supplements might be the answer you’ve been searching for.

NAD, or Nicotinamide Adenine Dinucleotide, plays a crucial role in cellular metabolism and energy production.

I’ve spent countless hours researching the best NAD supplements on the market and am excited to share my findings. These supplements offer a range of benefits, from improving cognitive function to supporting healthy aging, that can make a real difference in one’s life.

• Best NAD+ Supplement: NooCube NAD+
• Best NAD+ Supplement For Men Over 40: Prime Male Life
• Best NAD+ Supplement For Anti-Aging: Qualia NAD+
• Best Budget NAD+ Supplement: Double Wood NAD+ Supplement
• Best NAD+ Supplement On Amazon: Tru Niagen
• Best NAD+ Supplement With Resveratrol: Designs for Health CellGuard-NR NAD+ Supplement
• Best NMNH NAD+ Supplement: Double Wood NMNH

Best NAD+ Supplement

NooCube NAD+

Pros

• Fast-acting in increasing NAD+ levels
• Scientifically tested ingredients with proven benefits
• Supports overall energy and vitality
• Enhances cognitive functions, including memory and focus
• Promotes healthier aging through sirtuins activation

Cons

• Premium pricing may be a consideration for some
• Availability is mainly through specific online retailers
• Potential variability in individual response to the supplement

NAD Supplement	1 Bottle	3 Bottles	5 Bottles
NooCube NAD+	$64.99 ($2.17 per serving)	$129.99 ($1.44 per serving)	$194.99 ($1.30 per serving)

NooCube NAD+ stands out for its powerful formulation featuring Nicotinamide Riboside Chloride (NR).

This ingredient, a newly discovered form of vitamin B-3, is known for effectively and rapidly restoring fading NAD+ levels.

Unlike other nutrients that boost NAD+ levels, NR has garnered attention for its exceptional capability to elevate NAD+ levels higher and faster.

Pioneering human studies back this up, revealing NR’s unique ability to significantly enhance NAD+ levels, often to those comparable to much younger individuals.

The result?

Your cells are supercharged with energy, enabling them to resume critical renewal processes. This means you will not only feel more energetic but also look rejuvenated.

One of the exciting aspects of NooCube NAD+ is how it supports sirtuins, often referred to as the “secret to living longer and better.”

Sirtuins are DNA repair enzymes playing pivotal roles in the anti-aging process. They help maintain cellular health by repairing damaged DNA, promoting longevity and youthful vitality.

By boosting NAD+ levels, NooCube NAD+ effectively promotes the activity of sirtuins, which can help you live a healthier, more vibrant life.

Another notable benefit of NooCube NAD+ is its ability to combat age-related cognitive decline.

Higher NAD+ levels are associated with improved brain function, memory, and overall cognitive health. For anyone looking to maintain mental sharpness as they age, NooCube NAD+ offers an essential boost.

From my extensive research and firsthand experience, NooCube NAD+ stands out in the crowded market of NAD+ supplements.

Its unique formulation, backed by scientific studies, ensures you get the most out of every dose.

Whether you are seeking to enhance your energy levels, support healthy aging, or improve cognitive function, NooCube NAD+ presents a compelling option.

My NooCube NAD review goes into more detail about the supplement and my experience.

Best NAD+ Supplement For Men Over 40

Prime Male Life

Pros

• Clinically-dosed, scientifically-backed ingredients.
• Designed specifically for men over 40.
• It supports multiple aspects of health, including skin, heart, and metabolism.
• Reduces signs of aging such as wrinkles and fine lines.
• Free from additives, fillers, and heavy metals.

Cons

• Requires taking six capsules daily.
• Premium pricing compared to other longevity supplements.
• Effects on skin and energy levels may take several weeks to become noticeable.

NAD Supplement	1 Bottle	2 Bottles	4 Bottles
Prime Male Life	$79.99 ($2.67 per serving)	$159.98 ($2.67 per serving)	$239.96 ($2.00 per serving)

Prime Male Life is designed specifically for men and offers a comprehensive solution to the unique challenges of aging.

As an NAD+ boosting supplement, it helps to rejuvenate cellular health, enhance metabolism, and promote youthful vitality.

Packed with clinically supported ingredients, Prime Male Life improves energy levels and skin elasticity, optimizes heart and liver function, regulates blood sugar, and reduces inflammation.

A key ingredient, Nicotinamide Riboside, increases NAD+ levels, which is vital for slowing down aging and protecting against chronic diseases.

Additionally, ingredients like Trans-reveratrol and alpha-lipoic acid further aid in combating oxidative stress, improving skin health, and enhancing overall metabolic function.

The formula also features Betaine Anhydrous, known for supporting liver health and reducing homocysteine levels, a critical factor in cardiovascular health.

This supplement stands out for its NAD+ boosting properties and focus on male-specific health concerns, making it a top choice for men looking to age gracefully while maintaining high energy, vitality, and overall wellness.

Best NAD+ Supplement For Anti-Aging

Qualia NAD+

Pros

• Contains three NAD+ precursors (NIAGEN® Nicotinamide Riboside, niacin, and niacinamide) to ensure robust NAD+ production.
• Supports multiple pathways of cellular health, including energy production, mitochondrial function, and DNA repair.
• Features additional ingredients like resveratrol, Coffeeberry®, and magnesium to optimize NAD+ metabolism.
• Based on a pilot study, users reported improvements in energy, aging symptoms, and overall well-being.
• Full ingredient transparency with no proprietary blends.

Cons

• The product is relatively expensive compared to other NAD+ supplements.
• Early studies on the product have been small, and larger, placebo-controlled trials are needed to confirm results.
• Contains a small dose of caffeine from Coffeeberry®, which may not be ideal for those sensitive to stimulants.

NAD Supplement	One Time Purchase	Subscription 1st Month	Subscription 2nd Month Onward
Qualia NAD+	$69.00 ($2.30 per serving)	$29.00 ($0.97 per serving)	$59.00 ($1.97 per serving)

Qualia NAD+ is an advanced NAD+ boosting supplement designed to optimize the body’s natural ability to produce, utilize, and recycle NAD+, a crucial molecule for cellular health and longevity.

NAD+ plays a critical role in energy production, DNA repair, and overall cellular function, and its levels tend to decline as we age.

Qualia NAD+ addresses this decline through a carefully crafted blend of ingredients. It aims to increase NAD+ levels and support the entire process of NAD+ synthesis and function.

What sets Qualia NAD+ apart is its multi-faceted approach to NAD+ production. The formula combines three different precursors: NIAGEN® Nicotinamide Riboside, niacin, and niacinamide, ensuring that cells have multiple pathways to generate NAD+.

Additionally, the supplement includes supportive ingredients such as resveratrol, magnesium, and a fermented B vitamin complex to enhance ATP production, which is essential for cellular energy and NAD+ metabolism.

Through its comprehensive formulation, Qualia NAD+ not only helps increase NAD+ levels but also combats the signs of aging by promoting cellular longevity, supporting mitochondrial function, and boosting energy production.

In a preliminary open-label pilot study, 95% of participants rated their experience with Qualia NAD+ as “good” or “excellent,” and many reported improvements in energy, workout recovery, and overall vitality.

Although the study’s small sample size, these early results are promising for those looking to support healthy aging.

Best Budget NAD+ Supplement

Double Wood NAD+ Supplement

Pros

• Contains Nicotinamide Mononucleotide (NMN), a well-studied precursor to NAD+ that can raise NAD+ levels effectively.
• Affordable at around $40 for a one-month supply, making it accessible for budget-conscious individuals.
• Provides 125 mg of NMN per capsule, offering a balanced dosage for efficacy and cost.
• Easy-to-swallow capsules, designed for those who may struggle with larger pills.
• Clear and informative packaging with full ingredient transparency.
• Users often report improvements in energy, sleep quality, and focus after consistent use.

Cons

• The 125 mg dosage per capsule may be lower than other premium NAD+ supplements.
• Lacks additional supporting ingredients, like those found in more comprehensive NAD+ supplements.
• Benefits may take a few weeks to appear, requiring consistent, long-term use.
• Must be stored in a cool, dry place to maintain potency, which may be inconvenient for some.

NAD Supplement	One Time Purchase	Subscription
Double Wood NAD+ Supplement	$29.95 ($1.00 per serving)	$26.95 ($0.97 per serving)

Double Wood Supplements has earned a reputation for providing high-quality supplements at reasonable prices, and its NAD+ offering is no exception.

This product features Nicotinamide Mononucleotide (NMN), another precursor to NAD+ that has been shown to significantly elevate NAD+ levels in the body.

Double Wood’s NAD+ supplement provides 125 mg of NMN per capsule, and it is recommended that you take two capsules daily.

This dosage strikes a good balance between effectiveness and cost. The product comes in a 60-capsule bottle, providing a one-month supply with the recommended dosage.

The capsules are designed for easy swallowing, making the supplement accessible for those who may have difficulties with larger pills.

The packaging is straightforward and informative, listing all ingredients, dosage instructions, and additional information about NMN and its benefits.

In my experience, Double Wood’s NAD+ supplement performs admirably for its price point. After about two weeks of consistent use, I noticed improved energy levels and general well-being. The supplement also supports better sleep patterns and a more focused mind.

Like most supplements, Double Wood’s NAD+ capsules should be stored in a cool, dry place to maintain potency. The capsules are quite sturdy and dissolve well in the stomach, ensuring the NMN is effectively released and absorbed.

The daily regimen of two capsules is easy to follow. I appreciate that the dosage allows flexibility; depending on your schedule and how you feel, you can take both capsules at once or split them between morning and evening.

At around $40 per bottle, Double Wood’s NAD+ supplement offers excellent value for the money. Products with NMN can often be more expensive, but Double Wood manages to keep their costs low without compromising on quality.

This makes it an ideal choice for budget-conscious individuals seeking the health benefits of elevated NAD+ levels.

Best NAD+ Supplement On Amazon

Tru Niagen

Pros

• Contains Nicotinamide Riboside (NR), a highly researched form of vitamin B3 that directly elevates NAD+ levels.
• Backed by extensive scientific studies and clinical trials, providing a high level of confidence in its effectiveness.
• Patented NR formula (Niagen) with proven results in enhancing cellular health, energy, and supporting healthy aging.
• Non-GMO, vegetarian, and free from artificial colors and flavors, making it suitable for health-conscious consumers.
• Simple dosage of one capsule daily, making it easy to incorporate into a daily routine.
• Capsules are easy to swallow and have no aftertaste.

Cons

• More expensive than some alternatives, typically priced around $40 for a 30-day supply.
• The benefits may take a few weeks to become noticeable, requiring consistent use.
• Limited additional ingredients beyond NR might not offer a broader range of health benefits found in other NAD+ supplements.

NAD Supplement	30 Servings	90 Servings
Tru Niagen	$47.30 ($1.58 per serving)	$119.95 ($1.33 per serving)

You must be careful on Amazon, as studies show that 78% of NAD supplements contain less than 1% or 0% NAD ^[2].

Tru Niagen is a popular choice among NAD+ supplements. It contains Nicotinamide Riboside (NR), a form of vitamin B3 that explicitly targets and elevates NAD+ levels in the body.

What sets Tru Niagen apart is its scientific backing and rigorous testing. The key ingredient, NR, has been extensively studied and has shown promising results in enhancing cellular health and energy levels.

Tru Niagen is highly valued because of its patented NR formula, Niagen. Multiple clinical trials have demonstrated its effectiveness in safely increasing NAD+ levels ^[1].

For me, the appeal is in its transparency and extensive research, which makes it a reliable option for those serious about optimizing their health.

The product is easy to incorporate into a daily routine as it comes in convenient capsule form. The recommended dosage is one capsule daily, which simplifies the process.

The capsules are easy to swallow and have no noticeable aftertaste, making them user-friendly.

Also, Tru Niagen is non-GMO, vegetarian, and free from artificial colors and flavors, aligning with health-conscious consumers’ preferences.

Based on my experience and research, Tru Niagen’s main benefits include improved energy levels, better resistance to physical and mental stress, and support for healthy aging.

Users have reported feeling more energetic and focused, which aligns with the scientific evidence supporting NR’s efficacy.

While Tru Niagen is slightly more expensive than some alternatives, typically priced at around $40 for a 30-day supply, I believe the cost is justified given the quality and scientific validation.

For those looking to invest in a high-quality NAD+ supplement with proven benefits, Tru Niagen is a top contender.

Best NAD+ Supplement With Resveratrol

Designs for Health CellGuard-NR NAD+ Supplement

Pros

• Contains Niagen (Nicotinamide Riboside), a well-researched NAD+ precursor that supports cellular repair and anti-aging.
• Includes Resveratrol and Pterostilbene, two potent antioxidants known for reducing oxidative stress and protecting cells from damage.
• Offers a potent 300mg dose of NR per serving, helping to boost NAD+ levels and metabolism.
• Promotes overall cellular health and longevity, supporting DNA repair and anti-aging processes.
• Combines NAD+ precursors with antioxidants, providing a comprehensive solution for long-term cellular health.

Cons

• Higher price point compared to simpler NAD+ supplements due to the inclusion of Resveratrol and Pterostilbene.
• The 300mg dosage of NR may be too strong for sensitive individuals, potentially causing mild side effects like nausea.
• Availability may be limited to specific retailers, making it less accessible than other NAD+ supplements.

CellGuard-NR is uniquely formulated to nourish the body’s natural cellular repair processes. It includes Niagen, pterostilbene, and Resveratrol, both known for their anti-aging properties.

Combining these ingredients addresses oxidative stress and helps maintain healthy cells, which is crucial for aging gracefully.

NAD+ is a pivotal molecule in our bodies, involved in over 500 reactions, from gene expression to stress response and DNA repair.

This supplement provides NAD+ through Nicotinamide Riboside (NR), a compound proven to be a direct precursor to NAD+.

Following a regimen with NR can significantly enhance NAD+ levels, contributing to better cellular health and overall vitality.

With 300mg of NR in each serving, CellGuard-NR offers a potent dose to stimulate NAD+ metabolism.

Marked as an ‘anti-aging’ molecule, NAD+ is critical for supporting the body’s ongoing cellular maintenance and repair, helping to fend off the wear and tear associated with aging.

The inclusion of Resveratrol and Pterostilbene adds powerful antioxidants to the mix. Resveratrol is renowned for supporting a healthy oxidative stress response, vital for protecting cells from damage.

Pterostilbene, a compound similar to Resveratrol but with superior bioavailability, further enhances the formula’s effectiveness in promoting long-term health.

In my experience, Designs for Health CellGuard-NR offers a comprehensive approach to NAD+ supplementation. It’s about boosting NAD+ levels and providing a holistic blend supporting cellular health and longevity.

Including Resveratrol and Pterostilbene sets it apart from other supplements, offering additional protection and support.

Best NMNH NAD+ Supplement

Double Wood NMNH

Pros

• It contains 300mg of Nicotine Mononucleotide Hydrogen (NMNH), a new and faster-acting NAD+ precursor, making it more effective at raising NAD+ levels quickly.
• Non-GMO and gluten-free, making it suitable for those with dietary restrictions.
• Easy-to-swallow capsules and a straightforward daily dosage of two capsules, making it convenient for daily use.
• Provides noticeable energy boosts and cognitive improvements within the first week of use.
• It offers a competitive price point of around $50 for a 30-day supply, delivering fast and effective results compared to traditional NMN supplements.

Cons

• A newer formulation (NMNH) may have fewer long-term studies or user feedback than more established NAD+ precursors like NMN or NR.
• Some users may require longer-term use to notice full benefits in cellular repair and anti-aging effects.
• Might be less accessible in certain regions or through some retailers compared to other well-established NAD+ supplements.
• Potential for mild side effects if taken on an empty stomach or in sensitive individuals.

NAD Supplement	One Time Purchase	Subscription
Double Wood NAD+ Supplement	$59.89 ($1.00 per serving)	$53.90 ($0.90 per serving)

Double Wood’s NMNH supplement offers a promising addition to the market of NAD+ boosters.

This product capitalizes on Nicotinamide Mononucleotide Hydrogen (NMNH), a recent innovation in the NAD+ supplement sector.

As someone who has extensively researched NAD+ supplements, I find Double Wood’s approach noteworthy for several reasons.

• Contains 300mg of NMNH per serving
• Comes in a bottle with a 30-day supply
• Non-GMO and gluten-free
• Includes one other active ingredient to enhance absorption

Double Wood’s NMNH supplement is specially formulated to elevate NAD+ levels effectively. Unlike traditional NMN supplements, NMNH provides a significantly faster increase in NAD+ levels, making it a preferred choice for quick and potent results.

Each bottle contains 60 capsules, ensuring a one-month supply if taken as directed. The capsules are easy to swallow, making them suitable for daily use.

Taking Double Wood NMNH daily, I noticed a considerable boost in my energy levels within the first week. The fast absorption rate is one of the standout features, helping to enhance cellular energy production swiftly.

Notably, the supplement also supports improved cognitive functions and better stress resistance. The durability of effects is consistent, provided you adhere to the recommended dosage.

Double Wood NMNH excels in user convenience. The small, easy-to-swallow capsules fit seamlessly into my daily routine.

The recommended dosage is two capsules per day, and the instructions are simple and easy to follow, further enhancing user compliance and the overall experience.

When compared to other NMN-based supplements like Elysium Basis or ProHealth Longevity NMN Pro, Double Wood NMNH stands out for its rapid effectiveness and competitive pricing.

While Elysium Basis combines NR and PT (Pterostilbene), and NMN Pro focuses solely on NMN, Double Wood provides a unique edge with NMNH, ensuring quicker elevation of NAD+ levels.

Priced around $50 for a 30-day supply, Double Wood’s NMNH offers excellent value for money. The quality of ingredients and the formulation’s efficiency justify the cost.

What Is NAD+?

NAD+, or Nicotinamide Adenine Dinucleotide, is a critical coenzyme found in every cell of the body.

It plays a vital role in cellular metabolism by participating in redox reactions, which transfer electrons between molecules.

This transfer of electrons is essential for converting nutrients into energy, a process known as cellular respiration.

In simple terms, NAD+ acts like a shuttle, carrying electrons from one molecule to another, facilitating the production of ATP (adenosine triphosphate), cells’ primary energy currency.

Without sufficient NAD+ levels, our cells would struggle to produce the energy needed for everyday functions.

Interestingly, NAD+ also controls several other cellular processes. One key role is in activating sirtuins, a family of proteins that regulate cellular health, DNA repair, and stress resistance.

These proteins are often linked to longevity and overall aging processes, making NAD+ a powerhouse for energy and a guardian of cellular integrity.

As we age, our NAD+ levels naturally decline, which can contribute to the typical signs of aging, such as reduced energy, cognitive decline, and weakened cellular repair mechanisms.

This depletion of NAD+ underscores the growing interest in NAD+ supplements, which aim to replenish these levels and promote better health and vitality.

Supplements can contain different precursors to NAD+, such as Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN).

These compounds enter the body and convert to NAD+, helping maintain optimal cellular functioning levels.

With growing evidence supporting their benefits, these supplements are becoming popular tools in the fight against aging and energy depletion.

NAD+ isn’t just beneficial for its energy-boosting properties. Research has shown that maintaining optimal NAD+ levels can help improve cognitive function, support cardiovascular health, and enhance muscle performance.

This multi-faceted approach to health makes NAD+ a cornerstone for those looking to support their well-being.

How Do NAD+ Supplements Work?

NAD+ supplements work by replenishing the levels of Nicotinamide Adenine Dinucleotide (NAD+) in our bodies. NAD+ plays a crucial role in cellular metabolism and energy production.

As an essential coenzyme found in every cell, NAD+ facilitates redox reactions, helping convert nutrients into adenosine triphosphate (ATP), the cell’s energy currency.

This increase in cellular energy can have widespread benefits, from enhanced cognition to improved physical stamina.

NAD+ levels inevitably decline as we age, leading to decreased energy levels, cognitive impairments, and weaker cellular repair mechanisms.

By supplementing with NAD+, we can help counteract these age-related changes. Different NAD+ supplements employ varying compounds like Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN) to boost NAD+ levels effectively.

Efficacy of Different NAD+ Precursors

Nicotinamide Riboside (NR)

Studies show that NR is a highly effective NAD+ precursor that can significantly raise intracellular NAD+ levels.

Supplements containing NR, like NooCube NAD+, are often favored for their extensive research and proven benefits in elevating NAD+.

Nicotinamide Mononucleotide (NMN)

NMN is another potent NAD+ booster. It’s quickly converted into NAD+ within cells, making it an efficient supplement.

Double Wood NAD+ capitalizes on NMN’s rapid absorption to provide quick and noticeable benefits.

However, the FDA no longer classes NMN as a dietary supplement ^[3].

Benefits of NAD+ Supplements

Enhanced Cellular Energy Production

One of the primary benefits of NAD+ supplements is their role in boosting cellular energy production. NAD+ is essential for cellular metabolism, helping convert nutrients into ATP, the cell’s energy currency.

As NAD+ levels decline with age, energy production slows down, leading to fatigue and reduced vitality ^[4].

I’ve found that using these supplements can noticeably improve energy levels and endurance, making everyday activities and workouts more manageable.

Improved Cognitive Function

NAD+ supplementation has shown promising results in supporting brain health. By activating sirtuins, which are proteins involved in cellular health and longevity, NAD+ can help preserve cognitive function ^[5][6].

Many users, including myself, have reported improved focus, memory, and mental clarity when taking NAD+ supplements.

This is particularly beneficial for older adults or anyone looking to maintain sharp mental faculties as they age.

Support for Healthy Aging

Many people are concerned about healthy aging, and NAD+ supplements can be crucial.

These supplements help support DNA repair and cell regeneration, combating age-related cellular decline ^[7].

By maintaining higher levels of NAD+, I’ve experienced better skin health, robust immune function, and a generally more youthful appearance and feeling over time.

Enhanced Mitochondrial Function

Mitochondria, the cell’s powerhouse, rely heavily on NAD+ for optimal function. Improved mitochondrial performance means better energy production and reduced oxidative stress, critical for overall health ^[8][9].

Recent studies have shown that boosting NAD+ levels can significantly enhance mitochondrial function and reduce inflammation for those with chronic conditions like heart failure ^[10].

Activating Sirtuins for Longevity

Sirtuins, a family of proteins associated with cellular health and longevity, require NAD+ to function. When NAD+ levels are sufficient, sirtuins can better repair damaged DNA and regulate metabolic processes ^[12].

This aspect of NAD+ supplementation is crucial for reducing the risks of age-related diseases. For instance, the combination of NAD+ and Resveratrol in Designs for Health CellGuard-NR enhances sirtuin activity, supporting natural cell repair and longevity.

Reduced Inflammation

Inflammation is at the root of many chronic diseases, and NAD+ has been shown to have anti-inflammatory properties.

These supplements can help mitigate systemic inflammation by replenishing NAD+ levels, promoting better health outcomes ^[11].

Since taking NAD+ supplements, I’ve noticed less joint pain and quicker recovery times from workouts.

Better Muscle Health and Recovery

For fitness enthusiasts, NAD+ supplements can benefit muscle health and recovery. NAD+ supports muscle function and aids in repairing muscle tissue post-exercise ^[12].

I’ve experienced less muscle soreness and faster recovery times, allowing for more consistent and effective workouts.

Protection Against Neurodegeneration

NAD+ is also linked to neuroprotection, helping shield the brain from degenerative diseases like Alzheimer’s and Parkinson’s. By activating protective pathways, NAD+ can reduce the risk of these conditions.

This aspect is particularly reassuring for me, as I know that I’m taking proactive steps to protect my long-term brain health.

Improved Sleep Patterns

Quality sleep is fundamental to good health, and NAD+ supplements can improve sleep patterns ^[13].

These supplements help promote restful and restorative sleep by regulating circadian rhythms and reducing stress.

I’ve noticed improved sleep quality, which translates to better overall well-being.

Enhanced Metabolism

Maintaining a healthy metabolism is essential for weight management and overall health. NAD+ regulates metabolic processes, helping the body efficiently convert food into energy.

Since starting my NAD+ regimen, I’ve observed a more balanced metabolism, contributing to easier weight management.

How To Pick The Best NAD+ Supplements

Ingredients

One of the primary aspects I consider is the quality of the ingredients used in the supplements.

 NAD+ supplements commonly use precursors such as Nicotinamide Riboside (NR) and Nicotinamide Mononucleotide (NMN), both of which are known for their efficacy in boosting NAD+ levels.

• Nicotinamide Riboside (NR): Found in products like Tru Niagen and NooCube NAD+, NR has been extensively studied and shown to effectively elevate NAD+ levels. Its ability to improve cellular health and cognitive function makes it a top ingredient.
• Nicotinamide Mononucleotide (NMN): This ingredient is prevalent in options like Double Wood NAD+. NMN is another well-researched precursor known for its quick absorption and effective results in boosting NAD+ levels.
• Other Beneficial Additives: Some supplements incorporate additional compounds like Resveratrol and Pterostilbene, which are found in Designs for Health CellGuard-NR. These additives enhance the anti-aging benefits by complementing NAD+ functions.

Dosage

Appropriate dosage is crucial for effectiveness and safety. I look for supplements that clearly outline their recommended dosages and have been designed based on clinical research.

• Standard Dosage: Most reputable brands recommend a daily dosage of 250mg to 500mg for NR and NMN.
• Ease of Adjustment: Some products offer flexibility, allowing users to adjust the dosage based on their specific needs or as suggested by healthcare providers.

For example, Double Wood NAD+ recommends two capsules daily, each providing 500mg of NMN.

This dosage is in line with scientific studies suggesting its efficacy. Similarly, Tru Niagen suggests one capsule of 300mg of NR daily, validated through clinical trials.

Form

The form of the supplement significantly impacts its absorption and convenience.

• Capsules: Most top choices, like Tru Niagen and NooCube NAD+, come in easy-to-swallow capsules. This form ensures better absorption and is convenient for most users.
• Powder: Some supplements, like certain NMN products, are available in powder form. While these might offer flexibility in dosing, they may not be as convenient for everyone.
• Liquid: Though less common, a few brands offer liquid supplements, which can be beneficial for faster absorption but might not be as travel-friendly.

Third-Party Testing

Third-party testing is a non-negotiable criterion, given the importance of efficacy and safety in health supplements.

• Verified Quality: Products that have undergone third-party testing are typically more reliable. This testing ensures that the supplement contains what it claims and is free from harmful contaminants.
• Transparency: Brands publishing third-party test results demonstrate transparency and build trust. For instance, Double Wood and Tru Niagen openly share their testing certifications.

Price

While price is a consideration, weighing it against the quality and benefits offered is important.

• Balanced Value: I prioritize products that offer a good balance between cost and quality. For example, Double Wood NAD+ provides a month’s supply for around $40, making it a budget-friendly option without compromising on quality.
• Premium Options: Supplements like NooCube NAD+ and Designs for Health CellGuard-NR are priced higher. However, they justify their premium pricing through superior formulations and additional beneficial ingredients.

Frequently Asked NAD+ Supplement Questions

Are NAD+ Supplements Safe?

Yes, NAD+ supplements are generally considered safe for most people. They are backed by several clinical trials and studies demonstrating that they are well-tolerated.

But, it’s always wise to consult with a healthcare provider before starting any new supplement, especially if you have preexisting conditions or are taking other medications. This ensures you avoid any potential interactions or side effects.

How Long Does It Take to See Results?

The time it takes to see noticeable benefits from NAD+ supplements can vary among individuals.

Some people report feeling more energetic and mentally sharp within a few days, while others might not observe significant changes for a few weeks. Consistent use is key, so make sure you’re taking the recommended dosage regularly.

What is the Recommended Dosage for NAD+ Supplements?

Dosages can vary depending on the specific product and its formulation.

Generally, supplements like Tru Niagen and NooCube NAD+ suggest daily intakes ranging from 250mg to 300mg of Nicotinamide Riboside (NR), while products containing Nicotinamide Mononucleotide (NMN) might recommend similar amounts.

Always follow the manufacturer’s dosage instructions or consult a healthcare provider.

Can I Take NAD+ Supplements with Other Supplements?

NAD+ supplements can likely be taken alongside other supplements, but it’s essential to exercise caution.

Certain combinations may enhance effectiveness, while others might lead to interactions. Many individuals combine NAD+ with supplements like Resveratrol for synergistic anti-aging benefits.

But, I always recommend discussing any new supplement regimen with your healthcare provider to ensure it’s safe and effective for your needs.

Are There Any Side Effects?

Side effects from NAD+ supplementation are rare and usually mild. If they do occur, some may initially experience minor issues like nausea, headache, or mild digestive discomfort.

If you experience any severe side effects, discontinue use immediately and consult a healthcare professional.

Is NAD+ Worth the Investment?

For those committed to enhancing their overall health, longevity, and vitality, NAD+ supplements can be a worthwhile investment. They offer a plethora of benefits that can significantly improve quality of life. While some products might come with a higher price tag, their scientifically backed formulations assure you are investing in something genuinely beneficial for your health.

Summary

Exploring the best NAD+ supplements has revealed their incredible potential for boosting energy and supporting healthy aging. From premium options like NooCube NAD+ to budget-friendly choices like Double Wood, there’s a supplement for every need.

Tru Niagen’s scientific backing and the powerful Designs for Health CellGuard-NR combination offer compelling benefits.

Prioritizing high-quality ingredients and third-party testing ensures you get the best value and results. Incorporating NAD+ supplements into your routine can significantly enhance your overall well-being and vitality.

References

1. Conze, D., Brenner, C., & Kruger, C. L. (2019). Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Scientific reports, 9(1), 9772.
2. Quantitative Analysis of Twenty Two NMN Consumer Products (2021).
3. Information on Select Dietary Supplement Ingredients and Other Substances. FDA.gov
4. Covarrubias, A. J., Perrone, R., Grozio, A., & Verdin, E. (2021). NAD+ metabolism and its roles in cellular processes during ageing. Nature reviews Molecular cell biology, 22(2), 119-141.
5. Gong, B., Pan, Y., Vempati, P., Zhao, W., Knable, L., Ho, L., … & Pasinetti, G. M. (2013). Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-? coactivator 1? regulated ?-secretase 1 degradation and mitochondrial gene expression in Alzheimer’s mouse models. Neurobiology of aging, 34(6), 1581-1588.
6. Zhao, Y., Zhang, J., Zheng, Y., Zhang, Y., Zhang, X. J., Wang, H., … & Fu, J. (2021). NAD+ improves cognitive function and reduces neuroinflammation by ameliorating mitochondrial damage and decreasing ROS production in chronic cerebral hypoperfusion models through Sirt1/PGC-1? pathway. Journal of neuroinflammation, 18, 1-16.
7. Hogan, K. A., Chini, C. C., & Chini, E. N. (2019). The multi-faceted ecto-enzyme CD38: roles in immunomodulation, cancer, aging, and metabolic diseases. Frontiers in immunology, 10, 1187.
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